Heart failure (HF) is one of the chronic diseases that medicine struggles to effectively prevent, diagnose and treat. Yet, it remains the leading global cause of disability and premature death. A significant reduction of hospitalisations is a crucial step for the maintenance of patients’ life quality as well as for its burdening impact on the entire healthcare system’s efficiency. The EU-funded RETENTION project aims to develop an innovative platform supporting clinical decision-making and evidenced-based personalised interventions for HF patients. Through an automatised collection and analysis of patient data, the innovative solution will focus on reducing patients’ mortality and enhancing their quality of life.