The manufacturing ecosystem lacks a thorough cyber intelligence solution that addresses the key IIoT-related cybersecurity challenges towards a full realization of collaborative manufacturing in the context of Industry 4.0. COLLABS focuses on developing, validating, and demonstrating a comprehensive cyber-intelligence framework for collaborative manufacturing. This framework will enable secure data exchange across the digital supply chain while providing a high degree of resilience, reliability, accountability, and trustworthiness by addressing threat prevention, detection, mitigation, and real-time response. COLLABS is aimed at making significant scientific and technological advances in secure multi-party computation and homomorphic encryption, distributed deep learning and anomaly detection, distributed ledger technologies (blockchain) and smart contracts, and distributed remote software attestation.